Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons JA Parker, M Arango, S Abderrahmane, E Lambert, C Tourette, H Catoire, ... Nature genetics 37 (4), 349-350, 2005 | 631 | 2005 |
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis R Luthi-Carter, DM Taylor, J Pallos, E Lambert, A Amore, A Parker, ... Proceedings of the National Academy of Sciences 107 (17), 7927, 2010 | 387 | 2010 |
C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress I Melentijevic, ML Toth, ML Arnold, RJ Guasp, G Harinath, KC Nguyen, ... Nature 542 (7641), 367-371, 2017 | 332 | 2017 |
Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death JA Parker, JB Connolly, C Wellington, M Hayden, J Dausset, C Neri Proceedings of the National Academy of Sciences 98 (23), 13318-13323, 2001 | 285 | 2001 |
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase M Borrell-Pagès, JM Canals, FP Cordelières, JA Parker, JR Pineda, ... The Journal of clinical investigation 116 (5), 1410-1424, 2006 | 262 | 2006 |
Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegans M Therrien, GA Rouleau, PA Dion, JA Parker PloS one 8 (12), e83450, 2013 | 230 | 2013 |
Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity< i> in vivo</i> A Vaccaro, SA Patten, D Aggad, C Julien, C Maios, E Kabashi, P Drapeau, ... Neurobiology of Disease, 2013 | 142 | 2013 |
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans A Vaccaro, A Tauffenberger, D Aggad, G Rouleau, P Drapeau, JA Parker PloS one 7 (2), e31321, 2012 | 137 | 2012 |
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA A Aulas, G Caron, CG Gkogkas, NV Mohamed, L Destroismaisons, ... Journal of Cell Biology 209 (1), 73-84, 2015 | 124 | 2015 |
Mutations in CAPN1 cause autosomal-recessive hereditary spastic paraplegia Z Gan-Or, N Bouslam, N Birouk, A Lissouba, DB Chambers, J Vérièpe, ... The American Journal of Human Genetics 98 (5), 1038-1046, 2016 | 115 | 2016 |
Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio A Vaccaro, SA Patten, S Ciura, C Maios, M Therrien, P Drapeau, ... PLoS ONE 7 (7), e42117, 2012 | 112 | 2012 |
Restless legs syndrome‐associated MEIS1 risk variant influences iron homeostasis H Catoire, PA Dion, L Xiong, M Amari, R Gaudet, SL Girard, A Noreau, ... Annals of neurology 70 (1), 170-175, 2011 | 102 | 2011 |
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1 H Catoire, MY Pasco, A Abu-Baker, S Holbert, C Tourette, B Brais, ... Human molecular genetics 17 (14), 2108-2117, 2008 | 100 | 2008 |
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease RP Vázquez-Manrique, F Farina, K Cambon, M Dolores Sequedo, ... Human molecular genetics 25 (6), 1043-1058, 2016 | 98 | 2016 |
Pleiotropic effects of mTOR and autophagy during development and aging K Schmeisser, JA Parker Frontiers in cell and developmental biology 7, 192, 2019 | 97 | 2019 |
TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans A Vaccaro, A Tauffenberger, PEA Ash, Y Carlomagno, L Petrucelli, ... PLoS Genetics 8 (7), e1002806, 2012 | 95 | 2012 |
Equine stomachs harbor an abundant and diverse mucosal microbiota GA Perkins, HC Den Bakker, AJ Burton, HN Erb, SP McDonough, ... Applied and Environmental Microbiology 78 (8), 2522-2532, 2012 | 92 | 2012 |
Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis SA Patten, D Aggad, J Martinez, E Tremblay, J Petrillo, GAB Armstrong, ... JCI insight 2 (22), 2017 | 91 | 2017 |
Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons J Vérièpe, L Fossouo, JA Parker Nature communications 6 (1), 7319, 2015 | 88 | 2015 |
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity JA Parker, M Metzler, J Georgiou, M Mage, JC Roder, AM Rose, ... Journal of Neuroscience 27 (41), 11056-11064, 2007 | 81 | 2007 |