William P. Sheffield
William P. Sheffield
Canadian Blood Services and McMaster University (Professor)
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Cited by
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Mitochondrial precursor protein. Effects of 70-kilodalton heat shock protein on polypeptide folding, aggregation, and import competence.
WP Sheffield, GC Shore, SK Randall
Journal of Biological Chemistry 265 (19), 11069-11076, 1990
Potent antithrombin activity and delayed clearance from the circulation characterize recombinant hirudin genetically fused to albumin
S Syed, PD Schuyler, M Kulczycky, WP Sheffield
Blood, The Journal of the American Society of Hematology 89 (9), 3243-3252, 1997
Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate
MD Lambourne, LJ Eltringham‐Smith, S Gataiance, DM Arnold, ...
Journal of Thrombosis and Haemostasis 10 (9), 1830-1840, 2012
Molecular basis of inherited human antithrombin deficiency
MA Blajchman, RC Austin, F Fernandez-Rachubinski, WP Sheffield
Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin
SM Qadri, DA Donkor, V Bhakta, LJ Eltringham‐Smith, DJ Dwivedi, ...
Journal of cellular and molecular medicine 20 (4), 710-720, 2016
Quality assessment of established and emerging blood components for transfusion
JP Acker, DC Marks, WP Sheffield
Journal of blood transfusion 2016, 2016
Cytokeratin 18 is expressed on the hepatocyte plasma membrane surface and interacts with thrombin-antithrombin complexes
MJ Wells, MWC Hatton, B Hewlett, TJ Podor, WP Sheffield, MA Blajchman
Journal of Biological Chemistry 272 (45), 28574-28581, 1997
Modification of clearance of therapeutic and potentially therapeutic proteins
WP Sheffield
Current Drug Targets-Cardiovascular & Hematological Disorders 1 (1), 1-22, 2001
Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits
WP Sheffield, A Mamdani, G Hortelano, S Gataiance, L Eltringham‐Smith, ...
British journal of haematology 126 (4), 565-573, 2004
Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2
E Lang, R Bissinger, A Fajol, MS Salker, Y Singh, C Zelenak, ...
Scientific reports 5 (1), 17316, 2015
Prolonged in vivo anticoagulant activity of a hirudin–albumin fusion protein secreted from Pichia pastoris
WP Sheffield, IJ Smith, S Syed, V Bhakta
Blood coagulation & fibrinolysis 12 (6), 433-443, 2001
A barbourin-albumin fusion protein that is slowly cleared in vivo retains the ability to inhibit platelet aggregation in vitro
JA Marques, JK George, IJ Smith, V Bhakta, WP Sheffield
Thrombosis and haemostasis 86 (09), 902-908, 2001
Whole blood treated with riboflavin and ultraviolet light: quality assessment of all blood components produced by the buffy coat method
P Schubert, B Culibrk, S Karwal, K Serrano, E Levin, D Bu, V Bhakta, ...
Transfusion 55 (4), 815-823, 2015
Modulation of clearance of recombinant serum albumin by either glycosylation or truncation
WP Sheffield, JA Marques, V Bhakta, IJ Smith
Thrombosis research 99 (6), 613-621, 2000
Pathogen inactivation by riboflavin and ultraviolet light illumination accelerates the red blood cell storage lesion and promotes eryptosis
SM Qadri, D Chen, P Schubert, DL Perruzza, V Bhakta, DV Devine, ...
Transfusion 57 (3), 661-673, 2017
CD44 antibody inhibition of macrophage phagocytosis targets Fcγ receptor–and complement receptor 3–dependent mechanisms
A Amash, L Wang, Y Wang, V Bhakta, GD Fairn, M Hou, J Peng, ...
The Journal of Immunology 196 (8), 3331-3340, 2016
An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice
ME Begbie, A Mamdani, S Gataiance, LJ Eltringham-Smith, V Bhakta, ...
Thrombosis and haemostasis 94 (12), 1138-1147, 2005
Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa
DA Donkor, V Bhakta, LJ Eltringham-Smith, AR Stafford, JI Weitz, ...
Scientific Reports 7 (1), 2102, 2017
The clearance of thrombin-antithrombin and related serpin-enzyme complexes from the circulation: role of various hepatocyte receptors
MJ Wells, WP Sheffield, MA Blajchman
Thrombosis and haemostasis 81 (03), 325-337, 1999
Import of precursor proteins into mitochondria: site of polypeptide unfolding.
IS Skerjanc, WP Sheffield, SK Randall, JR Silvius, GC Shore
Journal of Biological Chemistry 265 (16), 9444-9451, 1990
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