Junwei Shi
Junwei Shi
Verified email at exchange.upenn.edu - Homepage
TitleCited byYear
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
JE Delmore, GC Issa, ME Lemieux, PB Rahl, J Shi, HM Jacobs, E Kastritis, ...
Cell 146 (6), 904-917, 2011
18892011
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
J Zuber, J Shi, E Wang, AR Rappaport, H Herrmann, EA Sison, D Magoon, ...
Nature 478 (7370), 524, 2011
13722011
The mechanisms behind the therapeutic activity of BET bromodomain inhibition
J Shi, CR Vakoc
Molecular cell 54 (5), 728-736, 2014
3912014
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
J Shi, E Wang, JP Milazzo, Z Wang, JB Kinney, CR Vakoc
Nature biotechnology 33 (6), 661, 2015
3492015
Roles of Arabidopsis WRKY18, WRKY40 and WRKY60 transcription factors in plant responses to abscisic acid and abiotic stress
H Chen, Z Lai, J Shi, Y Xiao, Z Chen, X Xu
BMC plant biology 10 (1), 281, 2010
3092010
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
J Shi, WA Whyte, CJ Zepeda-Mendoza, JP Milazzo, C Shen, JS Roe, ...
Genes & development 27 (24), 2648-2662, 2013
2252013
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
J Zuber, AR Rappaport, W Luo, E Wang, C Chen, AV Vaseva, J Shi, ...
Genes & development 25 (15), 1628-1640, 2011
1992011
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
B King, T Trimarchi, L Reavie, L Xu, J Mullenders, P Ntziachristos, ...
Cell 153 (7), 1552-1566, 2013
1972013
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
I Barbieri, K Tzelepis, L Pandolfini, J Shi, G Millán-Zambrano, SC Robson, ...
Nature 552 (7683), 126, 2017
1302017
Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem-and progenitor cells in acute myeloid leukemia (AML)
H Herrmann, K Blatt, J Shi, KV Gleixner, S Cerny-Reiterer, L Müllauer, ...
Oncotarget 3 (12), 1588, 2012
1302012
The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;NrasG12D acute myeloid leukemia
J Shi, E Wang, J Zuber, A Rappaport, M Taylor, C Johns, SW Lowe, ...
Oncogene 32 (7), 930, 2013
922013
Markers of tumor-initiating cells predict chemoresistance in breast cancer
C Gong, H Yao, Q Liu, J Chen, J Shi, F Su, E Song
PloS one 5 (12), e15630, 2010
862010
Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
E Wang, S Kawaoka, M Yu, J Shi, T Ni, W Yang, J Zhu, RG Roeder, ...
Proceedings of the National Academy of Sciences 110 (10), 3901-3906, 2013
852013
BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements
AS Bhagwat, JS Roe, BYL Mok, AF Hohmann, J Shi, CR Vakoc
Cell reports 15 (3), 519-530, 2016
642016
NSD3-short is an adaptor protein that couples BRD4 to the CHD8 chromatin remodeler
C Shen, JJ Ipsaro, J Shi, JP Milazzo, E Wang, JS Roe, Y Suzuki, ...
Molecular cell 60 (6), 847-859, 2015
602015
Optimized base editors enable efficient editing in cells, organoids and mice
MP Zafra, EM Schatoff, A Katti, M Foronda, M Breinig, AY Schweitzer, ...
Nature biotechnology 36 (9), 888, 2018
562018
Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
AF Hohmann, LJ Martin, JL Minder, JS Roe, J Shi, S Steurer, G Bader, ...
Nature chemical biology 12 (9), 672, 2016
522016
LKB1, salt-inducible kinases, and MEF2C are linked dependencies in acute myeloid leukemia
Y Tarumoto, B Lu, TDD Somerville, YH Huang, JP Milazzo, XS Wu, ...
Molecular cell 69 (6), 1017-1027. e6, 2018
242018
The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer
E Wang, S Kawaoka, JS Roe, J Shi, AF Hohmann, Y Xu, AS Bhagwat, ...
Elife 4, e06377, 2015
212015
Compositions and methods for treating leukemia
JE Bradner, J Zuber, J Shi, CR Vakoc, SW Lowe, CS Mitsiades
US Patent 9,815,849, 2017
192017
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Articles 1–20