Ming Chen

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Pier Paolo PandolfiDirector, Cancer Center and Cancer Research Institute, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
Jiaoti HuangDuke University School of medicineVerified email at duke.edu
Sabina SignorettiProfessor, Brigham and Women's Hospital, Harvard Medical SchoolVerified email at bwh.harvard.edu
John AsaraAssociate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
Jiangwen ZhangUniversity of Hong KongVerified email at hku.hk
Carlos Cordon-CardoChair, Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at MountVerified email at mssm.edu
Mireia Castillo-MartinVerified email at research.fchampalimaud.org
Lourdes MendezVerified email at bidmc.harvard.edu
YU-RU LEEInstitute of Biomedical Sciences, Academia SinicaVerified email at ibms.sinica.edu.tw
Antonella PapaCancer Biology and Cell Signalling Lab - Monash UniversityVerified email at monash.edu
Andrew WolfeAssociate Professor of Pediatrics, Johns Hopkins UniversityVerified email at jhmi.edu
Wenyi WeiProfessor, Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolVerified email at bidmc.harvard.edu
Jinfang ZhangInstructor, Beth Israel Deaconess Medical Center, Harvard Medical SchoolVerified email at bidmc.harvard.edu
Lixin WanH. Lee Moffitt Cancer Center and Research InstituteVerified email at moffitt.org
Mesut MuyanMiddle East Technical UniversityVerified email at metu.edu.tr
Leonardo SalmenaUniversity of TorontoVerified email at utoronto.ca
Andrew J. ArmstrongProfessor, Duke UniversityVerified email at duke.edu
Leszek KotulaUpstate Medical University, Syracuse, NYVerified email at upstate.edu
Qianben Wang, Ph.D.Professor of Pathology and Cell Biology, Duke University School of MedicineVerified email at duke.edu
Yuzhuo Wang, Ph.D. FCAHSProfessor of Urologic Sciences, UBCVerified email at bccrc.ca

Ming Chen

Associate Professor in Pathology, Duke University School of Medicine, Duke Cancer Institute

Verified email at duke.edu - Homepage

PTEN metastasis lipid metabolism ferroptosis mouse models


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The functions and regulation of the PTEN tumour suppressor: new modes and prospects YR Lee, M Chen, PP Pandolfi Nature reviews Molecular cell biology 19 (9), 547-562, 2018	692	2018
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer M Chen, J Zhang, K Sampieri, JG Clohessy, L Mendez, ... Nature genetics 50 (2), 206-218, 2018	267	2018
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway YR Lee, M Chen, JD Lee, J Zhang, SY Lin*, TM Fu, H Chen, T Ishikawa, ... Science 364 (6441), 2019	231	2019
Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery J Ni, M Chen, Y Zhang, R Li, J Huang, S Yeh Biochemical and biophysical research communications 300 (2), 357-363, 2003	181	2003
The expanded role of fatty acid metabolism in cancer: new aspects and targets M Chen, J Huang Precision clinical medicine 2 (3), 183-191, 2019	140	2019
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms M Bezzi, N Seitzer, T Ishikawa*, M Reschke, M Chen, G Wang, ... Nature medicine 24 (2), 165-175, 2018	140	2018
Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway J Ni, X Wen, J Yao, HC Chang, Y Yin, M Zhang, S Xie, M Chen, B Simons, ... Cancer research 65 (21), 9807-9816, 2005	109	2005
In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K–AKT signaling at endosomes CL Chew, A Lunardi, F Gulluni, DT Ruan, M Chen, L Salmena, ... Cancer discovery 5 (7), 740-751, 2015	102	2015
Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition E González-Billalabeitia, N Seitzer, SJ Song, MS Song, A Patnaik, XS Liu, ... Cancer discovery 4 (8), 896-904, 2014	96	2014
Defects of prostate development and reproductive system in the estrogen receptor-α null male mice M Chen, I Hsu, A Wolfe, S Radovick, KH Huang, S Yu, C Chang, ... Endocrinology 150 (1), 251-259, 2009	89	2009
CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells M Chen, J Ni, HC Chang, CY Lin, M Muyan, S Yeh Carcinogenesis 30 (5), 841-850, 2009	70	2009
SPOP promotes nanog destruction to suppress stem cell traits and prostate cancer progression J Zhang, M Chen, Y Zhu*, X Dai, F Dang, J Ren, S Ren, YV Shulga, ... Developmental cell 48 (3), 329-344. e5, 2019	62	2019
The APC/C E3 ligase complex activator FZR1 restricts BRAF oncogenic function L Wan, M Chen, J Cao, X Dai, Q Yin*, J Zhang, SJ Song, Y Lu, J Liu, ... Cancer discovery 7 (4), 424-441, 2017	61	2017
Generation and characterization of a complete null estrogen receptor α mouse using Cre/LoxP technology M Chen, A Wolfe, X Wang, C Chang, S Yeh, S Radovick Molecular and cellular biochemistry 321 (1), 145-153, 2009	54	2009
Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism M Chen, L Wan, J Zhang, J Zhang, L Mendez, JG Clohessy, K Berry, ... Nature communications 9 (1), 159, 2018	49	2018
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis A Lunardi, S Varmeh, M Chen, R Taulli, J Guarnerio, U Ala, N Seitzer, ... Cancer discovery 5 (5), 550-563, 2015	44	2015
Ornithine decarboxylase is sufficient for prostate tumorigenesis via androgen receptor signaling A Shukla-Dave, M Castillo-Martin, M Chen, J Lobo, N Gladoun, ... The American journal of pathology 186 (12), 3131-3145, 2016	41	2016
Loss of epithelial oestrogen receptor α inhibits oestrogen‐stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models M Chen, CR Yeh, HC Chang, S Vitkus, XQ Wen, NA Bhowmick, A Wolfe, ... The Journal of pathology 226 (1), 17-27, 2012	41	2012
Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy V Mugoni, R Panella, G Cheloni, M Chen*, O Pozdnyakova, ... Cell research 29 (6), 446-459, 2019	39	2019
Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling D Nath, X Li, C Mondragon, D Post, M Chen, JR White, ... Cell Communication and Signaling 17, 1-19, 2019	37	2019

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