C. Thomas Appleton
C. Thomas Appleton
Western University, Canada
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Cited by
Cited by
Global analyses of gene expression in early experimental osteoarthritis
CTG Appleton, V Pitelka, J Henry, F Beier
Arthritis & Rheumatism 56 (6), 1854-1868, 2007
Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis
CTG Appleton, DD McErlain, V Pitelka, N Schwartz, SM Bernier, JL Henry, ...
Arthritis research & therapy 9, 1-15, 2007
Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
CG James, CTG Appleton, V Ulici, TM Underhill, F Beier
Molecular biology of the cell 16 (11), 5316-5333, 2005
Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation
CTG Appleton, SE Usmani, JS Mort, F Beier
Laboratory investigation 90 (1), 20-30, 2010
Osteoarthritis year in review 2017: biology
CT Appleton
Osteoarthritis and cartilage 26 (3), 296-303, 2018
Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography
DD McErlain, CTG Appleton, RB Litchfield, V Pitelka, JL Henry, ...
Osteoarthritis and cartilage 16 (4), 458-469, 2008
Transforming growth factor α suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis
CTG Appleton, SE Usmani, SM Bernier, T Aigner, F Beier
Arthritis & Rheumatism: Official Journal of the American College of …, 2007
ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis
Y Lai, X Bai, Y Zhao, Q Tian, B Liu, EA Lin, Y Chen, B Lee, CT Appleton, ...
Annals of the rheumatic diseases 73 (8), 1575-1584, 2014
F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-β activation
MG Attur, GD Palmer, HE Al-Mussawir, M Dave, CC Teixeira, DB Rifkin, ...
The FASEB journal 23 (1), 79, 2009
Reduction in disease progression by inhibition of transforming growth factor α–CCL2 signaling in experimental posttraumatic osteoarthritis
CTG Appleton, SE Usmani, MA Pest, V Pitelka, JS Mort, F Beier
Arthritis & rheumatology 67 (10), 2691-2701, 2015
Molecular and histological analysis of a new rat model of experimental knee osteoarthritis
CTG Appleton, DD McERLAIN, JL Henry, DW Holdsworth, F Beier
Annals of the New York Academy of Sciences 1117 (1), 165-174, 2007
The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory …
DL Cecil, CTG Appleton, MD Polewski, JS Mort, AM Schmidt, A Bendele, ...
The Journal of Immunology 182 (8), 5024-5031, 2009
Regulator of G‐protein signaling (RGS) proteins differentially control chondrocyte differentiation
CTG Appleton, CG James, F Beier
Journal of cellular physiology 207 (3), 735-745, 2006
Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis
SA Ali, R Gandhi, P Potla, S Keshavarzi, O Espin-Garcia, K Shestopaloff, ...
Osteoarthritis and cartilage 28 (11), 1471-1481, 2020
Osteoarthritis, cerebrovascular dysfunction and the common denominator of inflammation: a narrative review
BK Al-Khazraji, CT Appleton, F Beier, TB Birmingham, JK Shoemaker
Osteoarthritis and Cartilage 26 (4), 462-470, 2018
Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic inflammation in …
JM Schulz, TB Birmingham, HF Atkinson, E Woehrle, CA Primeau, ...
British journal of sports medicine 54 (13), 771-775, 2020
Vascular smooth muscle cells as a valvular interstitial cell surrogate in heart valve tissue engineering
AJE Appleton, CTG Appleton, DR Boughner, KA Rogers
Tissue Engineering Part A 15 (12), 3889-3897, 2009
Association between changes in knee load and effusion-synovitis: evidence of mechano-inflammation in knee osteoarthritis using high tibial osteotomy as a model
HF Atkinson, TB Birmingham, CA Primeau, JM Schulz, CT Appleton, ...
Osteoarthritis and Cartilage 29 (2), 222-229, 2021
Strength in numbers: growth of Canadian clinician investigator training in the 21st century
CT Appleton, J Belrose, MR Ward, FB Young
Clinical and Investigative Medicine 36 (4), E163-E169, 2013
Transforming growth factor‐alpha induces endothelin receptor A expression in osteoarthritis
SE Usmani, CTG Appleton, F Beier
Journal of Orthopaedic Research 30 (9), 1391-1397, 2012
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