Hector Keun
Title
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Year
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
O Beckonert, HC Keun, TMD Ebbels, J Bundy, E Holmes, JC Lindon, ...
Nature protocols 2 (11), 2692-2703, 2007
16872007
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project
JC Lindon, JK Nicholson, E Holmes, H Antti, ME Bollard, H Keun, ...
Toxicology and applied pharmacology 187 (3), 137-146, 2003
4762003
Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass …
ECY Chan, PK Koh, M Mal, PY Cheah, KW Eu, A Backshall, R Cavill, ...
Journal of proteome research 8 (1), 352-361, 2009
4542009
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
O Beckonert, M Coen, HC Keun, Y Wang, TMD Ebbels, E Holmes, ...
Nature protocols 5 (6), 1019-1032, 2010
3402010
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements
JC Lindon, HC Keun, TMD Ebbels, JMT Pearce, E Holmes, JK Nicholson
Future Medicine Ltd 6 (7), 691-699, 2005
3022005
Analytical reproducibility in 1H NMR-based metabonomic urinalysis
HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, G Schlotterbeck, ...
Chemical research in toxicology 15 (11), 1380-1386, 2002
2872002
Summary recommendations for standardization and reporting of metabolic analyses
JC Lindon, JK Nicholson, E Holmes, HC Keun, A Craig, JTM Pearce, ...
Nature biotechnology 23 (7), 833-839, 2005
2792005
The human early-life exposome (HELIX): project rationale and design
M Vrijheid, R Slama, O Robinson, L Chatzi, M Coen, P Van den Hazel, ...
Environmental health perspectives 122 (6), 535-544, 2014
2482014
Impact of analytical bias in metabonomic studies of human blood serum and plasma
O Teahan, S Gamble, E Holmes, J Waxman, JK Nicholson, C Bevan, ...
Analytical chemistry 78 (13), 4307-4318, 2006
2452006
Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA
A Kamburov, R Cavill, TMD Ebbels, R Herwig, HC Keun
Bioinformatics 27 (20), 2917-2918, 2011
2432011
Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies
HC Keun, O Beckonert, JL Griffin, C Richter, D Moskau, JC Lindon, ...
Analytical chemistry 74 (17), 4588-4593, 2002
2242002
Metabonomic modeling of drug toxicity
HC Keun
Pharmacology & therapeutics 109 (1-2), 92-106, 2006
1982006
Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues
Y Wang, ME Bollard, H Keun, H Antti, O Beckonert, TM Ebbels, JC Lindon, ...
Analytical biochemistry 323 (1), 26-32, 2003
1982003
Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling
HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, E Holmes, ...
Analytica chimica acta 490 (1-2), 265-276, 2003
1962003
Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach
TMD Ebbels, HC Keun, OP Beckonert, ME Bollard, JC Lindon, E Holmes, ...
Journal of proteome research 6 (11), 4407-4422, 2007
1942007
NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches
O Beckonert, ME Bollard, TMD Ebbels, HC Keun, H Antti, E Holmes, ...
Analytica Chimica Acta 490 (1-2), 3-15, 2003
1652003
Metabolomics in toxicology and preclinical research
T Ramirez, M Daneshian, H Kamp, FY Bois, MR Clench, M Coen, ...
Altex 30 (2), 209, 2013
1612013
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
ME Dumas, SP Wilder, MT Bihoreau, RH Barton, JF Fearnside, K Argoud, ...
Nature genetics 39 (5), 666-672, 2007
1602007
Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles
HC Keun, TMD Ebbels, ME Bollard, O Beckonert, H Antti, E Holmes, ...
Chemical Research in Toxicology 17 (5), 579-587, 2004
1532004
Comparative metabonomics of differential hydrazine toxicity in the rat and mouse
ME Bollard, HC Keun, O Beckonert, TMD Ebbels, H Antti, AW Nicholls, ...
Toxicology and applied pharmacology 204 (2), 135-151, 2005
1452005
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