Megan Matthews
Megan Matthews
Assistant Professor, Department of Chemistry, University of Pennsylvania
Verified email at scripps.edu - Homepage
Title
Cited by
Cited by
Year
Substrate-triggered formation and remarkable stability of the C− H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2
ML Matthews, CM Krest, EW Barr, FH Vaillancourt, CT Walsh, MT Green, ...
Biochemistry 48 (20), 4331-4343, 2009
1932009
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates
JW Chang, MJ Niphakis, KM Lum, AB Cognetta III, C Wang, ML Matthews, ...
Chemistry & biology 19 (5), 579-588, 2012
1632012
Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2
ML Matthews, CS Neumann, LA Miles, TL Grove, SJ Booker, C Krebs, ...
Proceedings of the National Academy of Sciences 106 (42), 17723-17728, 2009
1612009
Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2
SD Wong, M Srnec, ML Matthews, LV Liu, Y Kwak, K Park, CB Bell III, ...
Nature 499 (7458), 320-323, 2013
1522013
Spectroscopic Evidence for a High-Spin Br-Fe(IV)-Oxo Intermediate in the α-Ketoglutarate-Dependent Halogenase CytC3 from Streptomyces
D Galonić Fujimori, EW Barr, ML Matthews, GM Koch, JR Yonce, ...
Journal of the American Chemical Society 129 (44), 13408-13409, 2007
1302007
Spectroscopic Evidence for a High-Spin Br-Fe(IV)-Oxo Intermediate in the α-Ketoglutarate-Dependent Halogenase CytC3 from Streptomyces
D Galonić Fujimori, EW Barr, ML Matthews, GM Koch, JR Yonce, ...
Journal of the American Chemical Society 129 (44), 13408-13409, 2007
1302007
Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase
ML Matthews, W Chang, AP Layne, LA Miles, C Krebs, JM Bollinger
Nature chemical biology 10 (3), 209-215, 2014
832014
Design of activated serine–containing catalytic triads with atomic-level accuracy
S Rajagopalan, C Wang, K Yu, AP Kuzin, F Richter, S Lew, AE Miklos, ...
Nature chemical biology 10 (5), 386-391, 2014
592014
myo-Inositol oxygenase: A radical new pathway for O 2 and C–H activation at a nonheme diiron cluster
JM Bollinger, Y Diao, ML Matthews, G Xing, C Krebs
Dalton Transactions, 905-914, 2009
542009
Chemical proteomic profiling of human methyltransferases
BD Horning, RM Suciu, DA Ghadiri, OA Ulanovskaya, ML Matthews, ...
Journal of the American Chemical Society 138 (40), 13335-13343, 2016
462016
2-oxoglutarate-dependent oxygenases
MJ Bollinger, J Myllyharju, R Trievel, T Muller, P Falnes, L Aravind, ...
Royal Society of Chemistry, 2015
44*2015
AurF from Streptomyces thioluteus and a Possible New Family of Manganese/Iron Oxygenases
C Krebs, ML Matthews, W Jiang, JM Bollinger
Biochemistry 46 (37), 10413-10418, 2007
432007
Electronic structure of the ferryl intermediate in the α-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H atom abstraction reactivity
M Srnec, SD Wong, ML Matthews, C Krebs, JM Bollinger Jr, EI Solomon
Journal of the American Chemical Society 138 (15), 5110-5122, 2016
422016
A five-coordinate metal center in Co (II)-substituted VanX
RM Breece, A Costello, B Bennett, TK Sigdel, ML Matthews, DL Tierney, ...
Journal of Biological Chemistry 280 (12), 11074-11081, 2005
392005
Chemoproteomic profiling and discovery of protein electrophiles in human cells
ML Matthews, L He, BD Horning, EJ Olson, BE Correia, JR Yates, ...
Nature chemistry 9 (3), 234-243, 2017
362017
The Nonribosomal Peptide Synthetase Enzyme DdaD Tethers Nβ-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by …
MA Hollenhorst, SB Bumpus, ML Matthews, JM Bollinger Jr, NL Kelleher, ...
Journal of the American Chemical Society 132 (44), 15773-15781, 2010
302010
Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical
EJ Blaesi, GM Palowitch, K Hu, AJ Kim, HR Rose, R Alapati, MG Lougee, ...
Proceedings of the National Academy of Sciences 115 (40), 10022-10027, 2018
242018
Mechanisms of 2-oxoglutarate-dependent oxygenases: the hydroxylation paradigm and beyond
JM Bollinger Jr, W Chang, ML Matthews, RJ Martinie, AK Boal, C Krebs
2-Oxoglutarate-dependent oxygenases, 95-122, 2015
242015
1131 CT Walsh, MT Green, C
ML Matthews, CM Krest, EW Barr, FH Vaillancourt
Krebs, JM Bollinger, Biochem-1132 istry 48, 4331-4343, 2009
242009
Novel approaches for the accumulation of oxygenated intermediates to multi-millimolar concentrations
C Krebs, LMK Dassama, ML Matthews, W Jiang, JC Price, V Korboukh, ...
Coordination chemistry reviews 257 (1), 234-243, 2013
212013
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