| In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist KJ Af Forselles, J Root, T Clarke, D Davey, K Aughton, K Dack, N Pullen British journal of pharmacology 164 (7), 1847-1856, 2011 | 161 | 2011 |
| Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition ABM Åstrand, M Hemmerling, J Root, C Wingren, J Pesic, E Johansson, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 308 (1 …, 2015 | 78 | 2015 |
| Dipeptidyl peptidase 1 inhibitor AZD7986 induces a sustained, exposure‐dependent reduction in neutrophil elastase activity in healthy subjects R Palmér, J Mäenpää, A Jauhiainen, B Larsson, J Mo, M Russell, J Root, ... Clinical Pharmacology & Therapeutics 104 (6), 1155-1164, 2018 | 67 | 2018 |
| Discovery of second generation reversible covalent DPP1 inhibitors leading to an oxazepane amidoacetonitrile based clinical candidate (AZD7986) K Doyle, H Lönn, H Käck, A Van de Poël, S Swallow, P Gardiner, ... Journal of Medicinal Chemistry 59 (20), 9457-9472, 2016 | 62 | 2016 |
| Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs JA Fernández-Blanco, D Fakih, L Arike, AM Rodríguez-Piñeiro, ... JCI insight 3 (17), 2018 | 44 | 2018 |
| Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5-d]azepines as Potent 5-Hydroxytryptamine 2C (5-HT2C) Receptor Agonists with Exquisite Functional … RI Storer, PE Brennan, AD Brown, PJ Bungay, KM Conlon, MS Corbett, ... Journal of Medicinal Chemistry 57 (12), 5258-5269, 2014 | 36 | 2014 |
| Targets of neutrophil influx and weaponry: therapeutic opportunities for chronic obstructive airway disease CK Mårdh, J Root, M Uddin, K Stenvall, A Malmgren, K Karabelas, ... Journal of immunology research 2017, 2017 | 28 | 2017 |
| Prostanoid receptors mediating contraction in rat, macaque and human bladder smooth muscle in vitro JA Root, DA Davey, KJA Forselles European Journal of Pharmacology 769, 274-279, 2015 | 18 | 2015 |
| Pyrimido [4, 5-d] azepines as potent and selective 5-HT2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence MD Andrews, PV Fish, J Blagg, TK Brabham, PE Brennan, A Bridgeland, ... Bioorganic & medicinal chemistry letters 21 (9), 2715-2720, 2011 | 14 | 2011 |
| Target engagement confirmed in man with a dipeptidyl peptidase 1 inhibitor K Stenvall, J Mo, M Russel, P Gardiner, R Palmer, A Jauhiainen, ... European Respiratory Journal 50 (suppl 61), 2017 | 5 | 2017 |
| Safety of medicine and the use of animals in research K Archibald, AD Baxter, K BeruBe, D Bunton, M Clotworthy, B Coleman, ... The Lancet 378 (9802), e2, 2011 | 5 | 2011 |
| Opioid receptor characterisation of neuronally stimulated isolated human vas deferens J Root, AMLC Wakenhut, H Siggins, S Katugampola, C Napier Naunyn-Schmiedeberg's archives of pharmacology 385, 1049-1052, 2012 | 3 | 2012 |
| Effect of alosetron and tegaserod at the 5-HT2B receptor in human colon RA Borman, J Wade, J Root, D Riddy, K Clark, B Coleman Gastroenterology 128 (4), A271-A271, 2005 | 3 | 2005 |
| Preclinical evaluation of the epithelial sodium channel inhibitor AZD5634 and implications on human translation A Åstrand, EF Libby, RJ Shei, JEP Lever, N Kaza, AT Adewale, E Boitet, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 323 (5 …, 2022 | 2 | 2022 |
| COPD lungs show an attached stratified mucus layer resembling the protective colonic mucus JA Fernández-Blanco, L Arike, A Ermund, D Fakih, AM Rodríguez-Piñeiro, ... BioRxiv, 205948, 2017 | 1 | 2017 |
| Inhibition of neutrophil serine protease activation with the reversible DPP1 inhibitor AZD7986 J Root, J Bernstrom, S Clifton, G Dahl, K Doyle, P Gardiner, ... C70. THE NEXT NEW THERAPEUTIC TARGET? TRANSLATIONAL STUDIES OF COPD …, 2016 | 1 | 2016 |
| A MODEL OF CHRONIC LUNG DISEASE AS IN CF SHOWS ATTACHED STRATIFIED MUCUS THAT RESEMBLES THE PROTECTIVE COLON MUCUS J Fernandez-Blanco, L Arike, A Ermund, D Fakih, AM Rodriguez-Pineiro, ... PEDIATRIC PULMONOLOGY 52, S250-S250, 2017 | | 2017 |
| Intranasal Elastase Induces Mucus Accumulation And Alterations In Lung Mucus Proteome In Mice JA Fernandez-Blanco, A Ermund, AM Rodriguez-Pineiro, J Root, ... A40. EPITHELIAL REGULATION OF INFLAMMATION, A1463-A1463, 2016 | | 2016 |
| C70 THE NEXT NEW THERAPEUTIC TARGET? TRANSLATIONAL STUDIES OF COPD THERAPIES: Inhibition Of Neutrophil Serine Protease Activation With The Reversible Dpp1 Inhibitor Azd7986 J Root, J Bernstrom, S Clifton, G Dahl, K Doyle, P Gardiner, ... American Journal of Respiratory and Critical Care Medicine 193, 1, 2016 | | 2016 |
| A40 EPITHELIAL REGULATION OF INFLAMMATION: Intranasal Elastase Induces Mucus Accumulation And Alterations In Lung Mucus Proteome In Mice J Fernandez-Blanco, A Ermund, A Rodriguez-Pineiro, J Root, C McCrae, ... American Journal of Respiratory and Critical Care Medicine 193, 1, 2016 | | 2016 |
