William Klein
William Klein
Verified email at northwestern.edu
Cited by
Cited by
Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
MP Lambert, AK Barlow, BA Chromy, C Edwards, R Freed, M Liosatos, ...
Proceedings of the National Academy of Sciences 95 (11), 6448-6453, 1998
Alzheimer's disease-affected brain: presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
Y Gong, L Chang, KL Viola, PN Lacor, MP Lambert, CE Finch, GA Krafft, ...
Proceedings of the National Academy of Sciences 100 (18), 10417-10422, 2003
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
WL Klein, GA Krafft, CE Finch
Trends in neurosciences 24 (4), 219-224, 2001
Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
PN Lacor, MC Buniel, PW Furlow, AS Clemente, PT Velasco, M Wood, ...
Journal of Neuroscience 27 (4), 796-807, 2007
Synaptic targeting by Alzheimer's-related amyloid β oligomers
PN Lacor, MC Buniel, L Chang, SJ Fernandez, Y Gong, KL Viola, ...
Journal of Neuroscience 24 (45), 10191-10200, 2004
Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor
AJ Haes, L Chang, WL Klein, RP Van Duyne
Journal of the American Chemical Society 127 (7), 2264-2271, 2005
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
DG Georganopoulou, L Chang, JM Nam, CS Thaxton, EJ Mufson, ...
Proceedings of the National Academy of Sciences 102 (7), 2273-2276, 2005
Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
FG De Felice, PT Velasco, MP Lambert, K Viola, SJ Fernandez, ...
Journal of Biological Chemistry 282 (15), 11590-11601, 2007
A localized surface plasmon resonance biosensor: First steps toward an assay for Alzheimer's disease
AJ Haes, WP Hall, L Chang, WL Klein, RP Van Duyne
Nano letters 4 (6), 1029-1034, 2004
Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets
WL Klein
Neurochemistry international 41 (5), 345-352, 2002
Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
HW Wang, JF Pasternak, H Kuo, H Ristic, MP Lambert, B Chromy, ...
Brain research 924 (2), 133-140, 2002
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
TR Bomfim, L Forny-Germano, LB Sathler, J Brito-Moreira, JC Houzel, ...
The Journal of clinical investigation 122 (4), 1339-1353, 2012
Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness
T Kondo, M Asai, K Tsukita, Y Kutoku, Y Ohsawa, Y Sunada, K Imamura, ...
Cell stem cell 12 (4), 487-496, 2013
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers
FG De Felice, MNN Vieira, TR Bomfim, H Decker, PT Velasco, ...
Proceedings of the National Academy of Sciences 106 (6), 1971-1976, 2009
Self-assembly of Aβ1-42 into globular neurotoxins
BA Chromy, RJ Nowak, MP Lambert, KL Viola, L Chang, PT Velasco, ...
Biochemistry 42 (44), 12749-12760, 2003
Cholesterol modulates α-secretase cleavage of amyloid precursor protein
S Bodovitz, WL Klein
Journal of Biological Chemistry 271 (8), 4436-4440, 1996
Amyloid beta oligomers induce impairment of neuronal insulin receptors
WQ Zhao, FG De Felice, S Fernandez, H Chen, MP Lambert, MJ Quon, ...
The FASEB Journal 22 (1), 246-260, 2008
Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease
WL Klein, WB Stine Jr, DB Teplow
Neurobiology of aging 25 (5), 569-580, 2004
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
FG De Felice, D Wu, MP Lambert, SJ Fernandez, PT Velasco, PN Lacor, ...
Neurobiology of aging 29 (9), 1334-1347, 2008
Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: a link between Aβ and tau pathology
S Oddo, A Caccamo, L Tran, MP Lambert, CG Glabe, WL Klein, ...
Journal of Biological Chemistry 281 (3), 1599-1604, 2006
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