William Klein
William Klein
Verified email at northwestern.edu
Title
Cited by
Cited by
Year
Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
MP Lambert, AK Barlow, BA Chromy, C Edwards, R Freed, M Liosatos, ...
Proceedings of the National Academy of Sciences 95 (11), 6448-6453, 1998
39981998
Alzheimer's disease-affected brain: presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
Y Gong, L Chang, KL Viola, PN Lacor, MP Lambert, CE Finch, GA Krafft, ...
Proceedings of the National Academy of Sciences 100 (18), 10417-10422, 2003
12662003
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
WL Klein, GA Krafft, CE Finch
Trends in neurosciences 24 (4), 219-224, 2001
12612001
Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
PN Lacor, MC Buniel, PW Furlow, AS Clemente, PT Velasco, M Wood, ...
Journal of Neuroscience 27 (4), 796-807, 2007
12492007
Synaptic targeting by Alzheimer's-related amyloid β oligomers
PN Lacor, MC Buniel, L Chang, SJ Fernandez, Y Gong, KL Viola, ...
Journal of Neuroscience 24 (45), 10191-10200, 2004
10682004
Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor
AJ Haes, L Chang, WL Klein, RP Van Duyne
Journal of the American Chemical Society 127 (7), 2264-2271, 2005
9592005
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
DG Georganopoulou, L Chang, JM Nam, CS Thaxton, EJ Mufson, ...
Proceedings of the National Academy of Sciences 102 (7), 2273-2276, 2005
9562005
Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
FG De Felice, PT Velasco, MP Lambert, K Viola, SJ Fernandez, ...
Journal of Biological Chemistry 282 (15), 11590-11601, 2007
8952007
A localized surface plasmon resonance biosensor: First steps toward an assay for Alzheimer's disease
AJ Haes, WP Hall, L Chang, WL Klein, RP Van Duyne
Nano letters 4 (6), 1029-1034, 2004
8492004
Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets
WL Klein
Neurochemistry international 41 (5), 345-352, 2002
7662002
Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
HW Wang, JF Pasternak, H Kuo, H Ristic, MP Lambert, B Chromy, ...
Brain research 924 (2), 133-140, 2002
6892002
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
TR Bomfim, L Forny-Germano, LB Sathler, J Brito-Moreira, JC Houzel, ...
The Journal of clinical investigation 122 (4), 1339-1353, 2012
6442012
Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness
T Kondo, M Asai, K Tsukita, Y Kutoku, Y Ohsawa, Y Sunada, K Imamura, ...
Cell stem cell 12 (4), 487-496, 2013
6372013
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers
FG De Felice, MNN Vieira, TR Bomfim, H Decker, PT Velasco, ...
Proceedings of the National Academy of Sciences 106 (6), 1971-1976, 2009
6352009
Self-assembly of Aβ1-42 into globular neurotoxins
BA Chromy, RJ Nowak, MP Lambert, KL Viola, L Chang, PT Velasco, ...
Biochemistry 42 (44), 12749-12760, 2003
6042003
Cholesterol modulates-secretase cleavage of amyloid precursor protein
S Bodovitz, WL Klein
Journal of Biological Chemistry 271 (8), 4436-4440, 1996
5781996
Amyloid beta oligomers induce impairment of neuronal insulin receptors
WQ Zhao, FG De Felice, S Fernandez, H Chen, MP Lambert, MJ Quon, ...
The FASEB Journal 22 (1), 246-260, 2008
5692008
Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease
WL Klein, WB Stine Jr, DB Teplow
Neurobiology of aging 25 (5), 569-580, 2004
5352004
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
FG De Felice, D Wu, MP Lambert, SJ Fernandez, PT Velasco, PN Lacor, ...
Neurobiology of aging 29 (9), 1334-1347, 2008
4822008
Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease A link between Aβ and tau pathology
S Oddo, A Caccamo, L Tran, MP Lambert, CG Glabe, WL Klein, ...
Journal of Biological Chemistry 281 (3), 1599-1604, 2006
4572006
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