| mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation M Morita, SP Gravel, V Chenard, K Sikström, L Zheng, T Alain, V Gandin, ... Cell metabolism 18 (5), 698-711, 2013 | 792 | 2013 |
| mTOR coordinates protein synthesis, mitochondrial activity and proliferation M Morita, SP Gravel, L Hulea, O Larsson, M Pollak, J St-Pierre, ... Cell Cycle 14 (4), 473-480, 2015 | 506 | 2015 |
| miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT MR Fabian, MK Cieplak, F Frank, M Morita, J Green, T Srikumar, B Nagar, ... Nature structural & molecular biology 18 (11), 1211-1217, 2011 | 404 | 2011 |
| mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1 M Morita, J Prudent, K Basu, V Goyon, S Katsumura, L Hulea, D Pearl, ... Molecular Cell 67 (6), 922-935. e5, 2017 | 300 | 2017 |
| La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1) BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ... Journal of Biological Chemistry 290 (26), 15996-16020, 2015 | 263 | 2015 |
| nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs V Gandin, L Masvidal, L Hulea, SP Gravel, M Cargnello, S McLaughlan, ... Genome research 26 (5), 636-648, 2016 | 219 | 2016 |
| Distinct perturbation of the translatome by the antidiabetic drug metformin O Larsson, M Morita, I Topisirovic, T Alain, MJ Blouin, M Pollak, ... Proceedings of the National Academy of Sciences 109 (23), 8977-8982, 2012 | 218 | 2012 |
| A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ... Molecular and cellular biology 32 (17), 3585-3593, 2012 | 216 | 2012 |
| Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale V Gandin, K Sikström, T Alain, M Morita, S McLaughlan, O Larsson, ... JoVE (Journal of Visualized Experiments), e51455, 2014 | 212 | 2014 |
| eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ... Cancer research 72 (24), 6468-6476, 2012 | 185 | 2012 |
| Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1 C Rouya, N Siddiqui, M Morita, TF Duchaine, MR Fabian, N Sonenberg Rna 20 (9), 1398-1409, 2014 | 159 | 2014 |
| The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability K Ito, A Takahashi, M Morita, T Suzuki, T Yamamoto Protein & cell 2 (9), 755-763, 2011 | 155 | 2011 |
| Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena YT Shirai, T Suzuki, M Morita, A Takahashi, T Yamamoto Frontiers in genetics 5, 286, 2014 | 137 | 2014 |
| Translation is actively regulated during the differentiation of CD8 (+) effector T cells. K Araki, M Morita, AG Bederman, BT Konieczny, HT Kissick, N Sonenberg, ... Nature immunology 18 (9), 1046, 2017 | 134 | 2017 |
| Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth M Morita, T Suzuki, T Nakamura, K Yokoyama, T Miyasaka, T Yamamoto Molecular and cellular biology 27 (13), 4980-4990, 2007 | 130 | 2007 |
| Crystal structure of the human CNOT6L nuclease domain reveals strict poly (A) substrate specificity H Wang, M Morita, X Yang, T Suzuki, W Yang, J Wang, K Ito, Q Wang, ... The EMBO journal 29 (15), 2566-2576, 2010 | 113 | 2010 |
| mTORC1 and CK2 coordinate ternary and eIF4F complex assembly V Gandin, L Masvidal, M Cargnello, L Gyenis, S McLaughlan, Y Cai, ... Nature communications 7 (1), 11127, 2016 | 103 | 2016 |
| Obesity resistance and increased hepatic expression of catabolism‐related mRNAs in Cnot3+/− mice M Morita, Y Oike, T Nagashima, T Kadomatsu, M Tabata, T Suzuki, ... The EMBO journal 30 (22), 4678-4691, 2011 | 85 | 2011 |
| CNOT2 depletion disrupts and inhibits the CCR4–NOT deadenylase complex and induces apoptotic cell death K Ito, T Inoue, K Yokoyama, M Morita, T Suzuki, T Yamamoto Genes to Cells 16 (4), 368-379, 2011 | 82 | 2011 |
| Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides L Hulea, SP Gravel, M Morita, M Cargnello, O Uchenunu, YK Im, ... Cell metabolism 28 (6), 817-832. e8, 2018 | 73 | 2018 |
Nahum SonenbergGilman Cheney Professor in BiochemistryVerified email at mcgill.ca
