Masahiro Morita
Masahiro Morita
Tenure-Track Assistant Professor (principal investigator), Department of Molecular Medicine and
Verified email at
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mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
M Morita, SP Gravel, V Chenard, K Sikström, L Zheng, T Alain, V Gandin, ...
Cell metabolism 18 (5), 698-711, 2013
mTOR coordinates protein synthesis, mitochondrial activity and proliferation
M Morita, SP Gravel, L Hulea, O Larsson, M Pollak, J St-Pierre, ...
Cell Cycle 14 (4), 473-480, 2015
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT
MR Fabian, MK Cieplak, F Frank, M Morita, J Green, T Srikumar, B Nagar, ...
Nature structural & molecular biology 18 (11), 1211-1217, 2011
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1
M Morita, J Prudent, K Basu, V Goyon, S Katsumura, L Hulea, D Pearl, ...
Molecular Cell 67 (6), 922-935. e5, 2017
La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1)
BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ...
Journal of Biological Chemistry 290 (26), 15996-16020, 2015
nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs
V Gandin, L Masvidal, L Hulea, SP Gravel, M Cargnello, S McLaughlan, ...
Genome research 26 (5), 636-648, 2016
Distinct perturbation of the translatome by the antidiabetic drug metformin
O Larsson, M Morita, I Topisirovic, T Alain, MJ Blouin, M Pollak, ...
Proceedings of the National Academy of Sciences 109 (23), 8977-8982, 2012
Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale
V Gandin, K Sikström, T Alain, M Morita, S McLaughlan, O Larsson, ...
JoVE (Journal of Visualized Experiments), e51455, 2014
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development
M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ...
Molecular and cellular biology 32 (17), 3585-3593, 2012
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies
T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ...
Cancer research 72 (24), 6468-6476, 2012
Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1
C Rouya, N Siddiqui, M Morita, TF Duchaine, MR Fabian, N Sonenberg
Rna 20 (9), 1398-1409, 2014
The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability
K Ito, A Takahashi, M Morita, T Suzuki, T Yamamoto
Protein & cell 2 (9), 755-763, 2011
Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena
YT Shirai, T Suzuki, M Morita, A Takahashi, T Yamamoto
Frontiers in genetics 5, 286, 2014
Translation is actively regulated during the differentiation of CD8 (+) effector T cells.
K Araki, M Morita, AG Bederman, BT Konieczny, HT Kissick, N Sonenberg, ...
Nature immunology 18 (9), 1046, 2017
Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth
M Morita, T Suzuki, T Nakamura, K Yokoyama, T Miyasaka, T Yamamoto
Molecular and cellular biology 27 (13), 4980-4990, 2007
Crystal structure of the human CNOT6L nuclease domain reveals strict poly (A) substrate specificity
H Wang, M Morita, X Yang, T Suzuki, W Yang, J Wang, K Ito, Q Wang, ...
The EMBO journal 29 (15), 2566-2576, 2010
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
V Gandin, L Masvidal, M Cargnello, L Gyenis, S McLaughlan, Y Cai, ...
Nature communications 7 (1), 11127, 2016
Obesity resistance and increased hepatic expression of catabolism‐related mRNAs in Cnot3+/− mice
M Morita, Y Oike, T Nagashima, T Kadomatsu, M Tabata, T Suzuki, ...
The EMBO journal 30 (22), 4678-4691, 2011
CNOT2 depletion disrupts and inhibits the CCR4–NOT deadenylase complex and induces apoptotic cell death
K Ito, T Inoue, K Yokoyama, M Morita, T Suzuki, T Yamamoto
Genes to Cells 16 (4), 368-379, 2011
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
L Hulea, SP Gravel, M Morita, M Cargnello, O Uchenunu, YK Im, ...
Cell metabolism 28 (6), 817-832. e8, 2018
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