| Synthesis of multifunctional spirocyclic azetidines and their application in drug discovery AA Kirichok, IO Shton, IM Pishel, SA Zozulya, PO Borysko, V Kubyshkin, ... Chemistry–A European Journal 24 (21), 5444-5449, 2018 | 54 | 2018 |
| Photochemical in-flow synthesis of 2, 4-methanopyrrolidines: pyrrolidine analogues with improved water solubility and reduced lipophilicity VV Levterov, O Michurin, PO Borysko, S Zozulya, IV Sadkova, ... The Journal of Organic Chemistry 83 (23), 14350-14361, 2018 | 49 | 2018 |
| Effect of gem‐Difluorination on the Key Physicochemical Properties Relevant to Medicinal Chemistry: The Case of Functionalized Cycloalkanes S Holovach, KP Melnykov, A Skreminskiy, M Herasymchuk, O Tavlui, ... Chemistry–A European Journal 28 (19), e202200331, 2022 | 43 | 2022 |
| In silico design of protein kinase inhibitors: successes and failures GG Dubinina, OO Chupryna, MO Platonov, PO Borisko, GV Ostrovska, ... Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2007 | 39 | 2007 |
| Novel 5, 7-disubstituted 6-amino-5H-pyrrolo [3, 2-b] pyrazine-2, 3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity GG Dubinina, MO Platonov, SM Golovach, PO Borysko, AO Tolmachov, ... European journal of medicinal chemistry 41 (6), 727-737, 2006 | 38 | 2006 |
| Photochemical synthesis of 2-azabicyclo [3.2. 0] heptanes: advanced building blocks for drug discovery. Synthesis of 2, 3-ethanoproline T Druzhenko, Y Skalenko, M Samoilenko, A Denisenko, S Zozulya, ... The Journal of Organic Chemistry 83 (3), 1394-1401, 2018 | 34 | 2018 |
| An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes S Chiba, T Ishida, K Ikeda, M Mochizuki, R Teramoto, YH Taguchi, ... Scientific Reports 7 (1), 12038, 2017 | 32 | 2017 |
| 2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring A Denisenko, P Garbuz, NM Voloshchuk, Y Holota, G Al-Maali, P Borysko, ... Nature Chemistry 15 (8), 1155-1163, 2023 | 29 | 2023 |
| SAR by space: enriching hit sets from the chemical space FM Klingler, M Gastreich, OO Grygorenko, O Savych, P Borysko, ... Molecules 24 (17), 3096, 2019 | 27 | 2019 |
| Straightforward hit identification approach in fragment-based discovery of bromodomain-containing protein 4 (BRD4) inhibitors P Borysko, YS Moroz, OV Vasylchenko, VV Hurmach, A Starodubtseva, ... Bioorganic & Medicinal Chemistry 26 (12), 3399-3405, 2018 | 22 | 2018 |
| Magnet for the needle in haystack:“crystal structure first” fragment hits unlock active chemical matter using targeted exploration of vast chemical spaces J Müller, R Klein, O Tarkhanova, A Gryniukova, P Borysko, S Merkl, ... Journal of Medicinal Chemistry 65 (23), 15663-15678, 2022 | 21 | 2022 |
| Facile one-pot transformation of primary alcohols into 3-aryl-and 3-alkyl-isoxazoles and-pyrazoles E Kobayashi, H Togo Synthesis 51 (19), 3723-3735, 2019 | 20 | 2019 |
| Oxa-spirocycles: synthesis, properties and applications K Fominova, T Diachuk, D Granat, T Savchuk, V Vilchynskyi, O Svitlychnyi, ... Chemical Science 12 (34), 11294-11305, 2021 | 19 | 2021 |
| A prospective compound screening contest identified broader inhibitors for Sirtuin 1 S Chiba, M Ohue, A Gryniukova, P Borysko, S Zozulya, N Yasuo, ... Scientific reports 9 (1), 19585, 2019 | 19 | 2019 |
| Pros and cons of virtual screening based on public “Big Data”: In silico mining for new bromodomain inhibitors I Casciuc, D Horvath, A Gryniukova, KA Tolmachova, OV Vasylchenko, ... European journal of medicinal chemistry 165, 258-272, 2019 | 18 | 2019 |
| Difluoromethyl Nitrile Oxide (CF2HCNO): A Neglected Chemical Reagent A Khutorianskyi, B Chalyk, P Borysko, A Kondratiuk, PK Mykhailiuk European Journal of Organic Chemistry 2017 (27), 3935-3940, 2017 | 18 | 2017 |
| (Chlorosulfonyl) benzenesulfonyl fluorides—versatile building blocks for combinatorial chemistry: design, synthesis and evaluation of a covalent inhibitor library KA Tolmachova, YS Moroz, A Konovets, MO Platonov, OV Vasylchenko, ... ACS Combinatorial Science 20 (11), 672-680, 2018 | 17 | 2018 |
| Phosphine Oxides (−POMe2) for Medicinal Chemistry: Synthesis, Properties, and Applications MV Stambirskyi, T Kostiuk, SI Sirobaba, A Rudnichenko, DL Titikaiev, ... The Journal of Organic Chemistry 86 (18), 12783-12801, 2021 | 16 | 2021 |
| Continued SAR exploration of 1, 2, 4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists M Krasavin, A Lukin, A Bakholdina, N Zhurilo, O Onopchenko, P Borysko, ... European Journal of Medicinal Chemistry 140, 229-238, 2017 | 14 | 2017 |
| Anionic amphiphilic calixarenes for peptide assembly and delivery RV Rodik, SO Cherenok, VY Postupalenko, S Oncul, V Brusianska, ... Journal of Colloid and Interface Science 624, 270-278, 2022 | 13 | 2022 |
