| RBR E3 ubiquitin ligases: new structures, new insights, new questions DE Spratt, H Walden, GS Shaw Biochemical journal 458 (3), 421-437, 2014 | 314 | 2014 |
| Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis A Kumar, JD Aguirre, TEC Condos, RJ Martinez‐Torres, VK Chaugule, ... The EMBO journal 34 (20), 2506-2521, 2015 | 172 | 2015 |
| A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease DE Spratt, R Julio Martinez-Torres, YJ Noh, P Mercier, N Manczyk, ... Nature communications 4 (1), 1983, 2013 | 132 | 2013 |
| HECT E3 ubiquitin ligases–emerging insights into their biological roles and disease relevance Y Wang, D Argiles-Castillo, EI Kane, A Zhou, DE Spratt Journal of cell science 133 (7), jcs228072, 2020 | 102 | 2020 |
| Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras E Newman, DE Spratt, J Mosher, B Cheyne, HJ Montgomery, DL Wilson, ... Journal of Biological Chemistry 279 (32), 33547-33557, 2004 | 70 | 2004 |
| Differential binding of calmodulin domains to constitutive and inducible nitric oxide synthase enzymes DE Spratt, V Taiakina, M Palmer, JG Guillemette Biochemistry 46 (28), 8288-8300, 2007 | 61 | 2007 |
| Structure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutation M Piazza, K Futrega, DE Spratt, T Dieckmann, JG Guillemette Biochemistry 51 (17), 3651-3661, 2012 | 56 | 2012 |
| Selective recruitment of an E2∼ ubiquitin complex by an E3 ubiquitin ligase DE Spratt, K Wu, J Kovacev, ZQ Pan, GS Shaw Journal of Biological Chemistry 287 (21), 17374-17385, 2012 | 55 | 2012 |
| Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs DE Spratt, E Newman, J Mosher, DK Ghosh, JC Salerno, JG Guillemette The FEBS journal 273 (8), 1759-1771, 2006 | 54 | 2006 |
| Suramin inhibits cullin-RING E3 ubiquitin ligases K Wu, RA Chong, Q Yu, J Bai, DE Spratt, K Ching, C Lee, H Miao, I Tappin, ... Proceedings of the National Academy of Sciences 113 (14), E2011-E2018, 2016 | 48 | 2016 |
| Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme C Feng, AL Dupont, NJ Nahm, DE Spratt, JT Hazzard, JB Weinberg, ... JBIC Journal of Biological Inorganic Chemistry 14, 133-142, 2009 | 38 | 2009 |
| Generation of phospho‐ubiquitin variants by orthogonal translation reveals codon skipping S George, JD Aguirre, DE Spratt, Y Bi, M Jeffery, GS Shaw, P O'Donoghue FEBS letters 590 (10), 1530-1542, 2016 | 36 | 2016 |
| Calcium-deficient calmodulin binding and activation of neuronal and inducible nitric oxide synthases DE Spratt, V Taiakina, JG Guillemette Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (10), 1351-1358, 2007 | 30 | 2007 |
| HERC5 and the ISGylation pathway: critical modulators of the antiviral immune response NA Mathieu, E Paparisto, SD Barr, DE Spratt Viruses 13 (6), 1102, 2021 | 29 | 2021 |
| Association of the disordered C-terminus of CDC34 with a catalytically bound ubiquitin DE Spratt, GS Shaw Journal of molecular biology 407 (3), 425-438, 2011 | 26 | 2011 |
| Dual-targeted labeling of proteins using cysteine and selenomethionine residues S Lang, DE Spratt, JG Guillemette, M Palmer Analytical biochemistry 342 (2), 271-279, 2005 | 25 | 2005 |
| Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination RA Chong, K Wu, DE Spratt, Y Yang, C Lee, J Nayak, M Xu, R Elkholi, ... Proceedings of the National Academy of Sciences 111 (23), 8434-8439, 2014 | 23 | 2014 |
| Codon optimization for enhanced Escherichia coli expression of human S100A11 and S100A1 proteins NM Marlatt, DE Spratt, GS Shaw Protein expression and purification 73 (1), 58-64, 2010 | 23 | 2010 |
| Resveratrol sustains insulin-degrading enzyme activity toward Aβ42 CA Krasinski, VA Ivancic, Q Zheng, DE Spratt, ND Lazo ACS omega 3 (10), 13275-13282, 2018 | 19 | 2018 |
| A subset of calcium‐binding S100 proteins show preferential heterodimerization DE Spratt, KR Barber, NM Marlatt, V Ngo, JA Macklin, Y Xiao, ... The FEBS journal 286 (10), 1859-1876, 2019 | 18 | 2019 |
Gary ShawProfessor of Biochemistry, University of Western Ontario, London, Ontario, CanadaVerified email at uwo.ca
