Donald E. Spratt
Donald E. Spratt
Associate Professor of Chemistry & Biochemistry, Clark University, Worcester MA USA
Verified email at - Homepage
Cited by
Cited by
RBR E3 ubiquitin ligases: new structures, new insights, new questions
DE Spratt, H Walden, GS Shaw
Biochemical journal 458 (3), 421-437, 2014
Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis
A Kumar, JD Aguirre, TEC Condos, RJ Martinez‐Torres, VK Chaugule, ...
The EMBO journal 34 (20), 2506-2521, 2015
A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
DE Spratt, R Julio Martinez-Torres, YJ Noh, P Mercier, N Manczyk, ...
Nature communications 4 (1), 1983, 2013
HECT E3 ubiquitin ligases–emerging insights into their biological roles and disease relevance
Y Wang, D Argiles-Castillo, EI Kane, A Zhou, DE Spratt
Journal of cell science 133 (7), jcs228072, 2020
Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras
E Newman, DE Spratt, J Mosher, B Cheyne, HJ Montgomery, DL Wilson, ...
Journal of Biological Chemistry 279 (32), 33547-33557, 2004
Differential binding of calmodulin domains to constitutive and inducible nitric oxide synthase enzymes
DE Spratt, V Taiakina, M Palmer, JG Guillemette
Biochemistry 46 (28), 8288-8300, 2007
Selective recruitment of an E2∼ ubiquitin complex by an E3 ubiquitin ligase
DE Spratt, K Wu, J Kovacev, ZQ Pan, GS Shaw
Journal of Biological Chemistry 287 (21), 17374-17385, 2012
Structure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutation
M Piazza, K Futrega, DE Spratt, T Dieckmann, JG Guillemette
Biochemistry 51 (17), 3651-3661, 2012
Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs
DE Spratt, E Newman, J Mosher, DK Ghosh, JC Salerno, JG Guillemette
The FEBS journal 273 (8), 1759-1771, 2006
Suramin inhibits cullin-RING E3 ubiquitin ligases
K Wu, RA Chong, Q Yu, J Bai, DE Spratt, K Ching, C Lee, H Miao, I Tappin, ...
Proceedings of the National Academy of Sciences 113 (14), E2011-E2018, 2016
Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme
C Feng, AL Dupont, NJ Nahm, DE Spratt, JT Hazzard, JB Weinberg, ...
JBIC Journal of Biological Inorganic Chemistry 14, 133-142, 2009
HERC5 and the ISGylation pathway: critical modulators of the antiviral immune response
NA Mathieu, E Paparisto, SD Barr, DE Spratt
Viruses 13 (6), 1102, 2021
Generation of phospho‐ubiquitin variants by orthogonal translation reveals codon skipping
S George, JD Aguirre, DE Spratt, Y Bi, M Jeffery, GS Shaw, P O'Donoghue
FEBS letters 590 (10), 1530-1542, 2016
Calcium-deficient calmodulin binding and activation of neuronal and inducible nitric oxide synthases
DE Spratt, V Taiakina, JG Guillemette
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (10), 1351-1358, 2007
Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination
RA Chong, K Wu, DE Spratt, Y Yang, C Lee, J Nayak, M Xu, R Elkholi, ...
Proceedings of the National Academy of Sciences 111 (23), 8434-8439, 2014
Dual-targeted labeling of proteins using cysteine and selenomethionine residues
S Lang, DE Spratt, JG Guillemette, M Palmer
Analytical biochemistry 342 (2), 271-279, 2005
Association of the disordered C-terminus of CDC34 with a catalytically bound ubiquitin
DE Spratt, GS Shaw
Journal of molecular biology 407 (3), 425-438, 2011
Codon optimization for enhanced Escherichia coli expression of human S100A11 and S100A1 proteins
NM Marlatt, DE Spratt, GS Shaw
Protein Expression and Purification 73 (1), 58-64, 2010
Resveratrol sustains insulin-degrading enzyme activity toward Aβ42
CA Krasinski, VA Ivancic, Q Zheng, DE Spratt, ND Lazo
ACS omega 3 (10), 13275-13282, 2018
Structural insights into ankyrin repeat-containing proteins and their influence in ubiquitylation
EI Kane, DE Spratt
International journal of molecular sciences 22 (2), 609, 2021
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