Philip j Thomas
Philip j Thomas
Professor UT Southwestern
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TitleCited byYear
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer
PC Smith, N Karpowich, L Millen, JE Moody, J Rosen, PJ Thomas, ...
Molecular cell 10 (1), 139-149, 2002
Defective protein folding as a basis of human disease
PJ Thomas, BH Qu, PL Pedersen
Trends in biochemical sciences 20 (11), 456-459, 1995
Dynamic association of proteasomal machinery with the centrosome
W Christian Wigley, RP Fabunmi, MG Lee, CR Marino, S Muallem, ...
The Journal of cell biology 145 (3), 481-490, 1999
Structure of nucleotide‐binding domain 1 of the cystic fibrosis transmembrane conductance regulator
HA Lewis, SG Buchanan, SK Burley, K Conners, M Dickey, M Dorwart, ...
The EMBO journal 23 (2), 282-293, 2004
Endoproteolytic activity of the proteasome
CW Liu, MJ Corboy, GN DeMartino, PJ Thomas
Science 299 (5605), 408-411, 2003
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene
PR Sosnay, KR Siklosi, F Van Goor, K Kaniecki, H Yu, N Sharma, ...
Nature genetics 45 (10), 1160, 2013
Gating of CFTR by the STAS domain of SLC26 transporters
SBH Ko, W Zeng, MR Dorwart, X Luo, KH Kim, L Millen, H Goto, S Naruse, ...
Nature cell biology 6 (4), 343-350, 2004
Aberrant CFTR-dependent HCO-3 transport in mutations associated with cystic fibrosis
JY Choi, D Muallem, K Kiselyov, MG Lee, PJ Thomas, S Muallem
Nature 410 (6824), 94-97, 2001
Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters
JE Moody, L Millen, D Binns, JF Hunt, PJ Thomas
Journal of Biological Chemistry 277 (24), 21111-21114, 2002
Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter
N Karpowich, O Martsinkevich, L Millen, YR Yuan, PL Dai, K MacVey, ...
Structure 9 (7), 571-586, 2001
The crystal structure of the MJ0796 ATP-binding cassette Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter
YR Yuan, S Blecker, O Martsinkevich, L Millen, PJ Thomas, JF Hunt
Journal of Biological Chemistry 276 (34), 32313-32321, 2001
A molecular mechanism for aberrantCFTR‐dependent HCO3− transport in cystic fibrosis
SBH Ko, N Shcheynikov, JY Choi, X Luo, K Ishibashi, PJ Thomas, JY Kim, ...
The EMBO journal 21 (21), 5662-5672, 2002
The HUman MicroNucleus project on eXfoLiated buccal cells (HUMNXL): The role of life-style, host factors, occupational exposures, health status, and assay protocol
S Bonassi, E Coskun, M Ceppi, C Lando, C Bolognesi, S Burgaz, ...
Mutation Research/Reviews in Mutation Research 728 (3), 88-97, 2011
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices
JMR Baker, RP Hudson, V Kanelis, WY Choy, PH Thibodeau, PJ Thomas, ...
Nature structural & molecular biology 14 (8), 738-745, 2007
GABA A receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1
FK Bedford, JT Kittler, E Muller, P Thomas, JM Uren, D Merlo, W Wisden, ...
Nature neuroscience 4 (9), 908-916, 2001
Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin
AR Humpage, M Fenech, P Thomas, IR Falconer
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 472 (1-2 …, 2000
A Precipitating Role for Truncated α-Synuclein and the Proteasome in α-Synuclein Aggregation IMPLICATIONS FOR PATHOGENESIS OF PARKINSON DISEASE
CW Liu, BI Giasson, KA Lewis, VM Lee, GN DeMartino, PJ Thomas
Journal of Biological Chemistry 280 (24), 22670-22678, 2005
Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome
E Strickland, K Hakala, PJ Thomas, GN DeMartino
Journal of Biological Chemistry 275 (8), 5565-5572, 2000
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
DM Hutt, D Herman, APC Rodrigues, S Noel, JM Pilewski, J Matteson, ...
Nature chemical biology 6 (1), 25, 2010
Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay
P Thomas, K Umegaki, M Fenech
Mutagenesis 18 (2), 187-194, 2003
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