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Seng H. Cheng
Seng H. Cheng
Alexion, AstraZeneca Rare Disease
Verified email at alexion.com
Title
Cited by
Cited by
Year
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
SH Cheng, RJ Gregory, J Marshall, S Paul, DW Souza, GA White, ...
Cell 63 (4), 827-834, 1990
21551990
Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis
HB Kordasiewicz, LM Stanek, EV Wancewicz, C Mazur, MM McAlonis, ...
Neuron 74 (6), 1031-1044, 2012
8322012
Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells
DP Rich, MP Anderson, RJ Gregory, SH Cheng, S Paul, DM Jefferson, ...
Nature 347 (6291), 358-363, 1990
8161990
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel
SH Cheng, DP Rich, J Marshall, RJ Gregory, MJ Welsh, AE Smith
Cell 66 (5), 1027-1036, 1991
8001991
Nomenclature for synthetic gene delivery systems
PL Felgner, Y Barenholz, JP Behr, SH Cheng, P Cullis, L Huang, ...
Human gene therapy 8 (5), 511-512, 1997
6491997
Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung
ER Lee, J Marshall, CS Siegel, C Jiang, NS Yew, MR Nichols, ...
Human gene therapy 7 (14), 1701-1717, 1996
6191996
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src
H Piwnica-Worms, KB Saunders, TM Roberts, AE Smith, SH Cheng
Cell 49 (1), 75-82, 1987
6131987
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial
E Alton, M Stern, R Farley, A Jaffe, SL Chadwick, J Phillips, J Davies, ...
The Lancet 353 (9157), 947-954, 1999
5611999
Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy
MA Passini, J Bu, AM Richards, C Kinnecom, SP Sardi, LM Stanek, Y Hua, ...
Science translational medicine 3 (72), 72ra18-72ra18, 2011
5602011
Targeting nuclear RNA for in vivo correction of myotonic dystrophy
TM Wheeler, AJ Leger, SK Pandey, AR MacLeod, M Nakamori, SH Cheng, ...
Nature 488 (7409), 111-115, 2012
5212012
Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial
EWFW Alton, DK Armstrong, D Ashby, KJ Bayfield, D Bilton, ...
The Lancet Respiratory Medicine 3 (9), 684-691, 2015
5012015
Expression and characterization of the cystic fibrosis transmembrane conductance regulator
RJ Gregory, SH Cheng, DP Rich, J Marshall, S Paul, K Hehir, ...
Nature 347 (6291), 382-386, 1990
4681990
Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
M Yamakawa, LX Liu, T Date, AJ Belanger, KA Vincent, GY Akita, ...
Circulation research 93 (7), 664-673, 2003
4622003
A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung.
CJ Wheeler, PL Felgner, YJ Tsai, J Marshall, L Sukhu, SG Doh, J Hartikka, ...
Proceedings of the National Academy of Sciences 93 (21), 11454-11459, 1996
4001996
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
SC Hyde, IA Pringle, S Abdullah, AE Lawton, LA Davies, A Varathalingam, ...
Nature biotechnology 26 (5), 549-551, 2008
3692008
Acid β‐glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α‐synuclein processing
V Cullen, SP Sardi, J Ng, YH Xu, Y Sun, JJ Tomlinson, P Kolodziej, I Kahn, ...
Annals of neurology 69 (6), 940-953, 2011
3532011
Improved cationic lipid formulations for in vivo gene therapy.
PL Felgner, YJ Tsai, L Sukhu, CJ Wheeler, M Manthorpe, J Marshall, ...
Annals of the New York Academy of Sciences 772, 126-139, 1995
3531995
Biophysical characterization of cationic lipid: DNA complexes
SJ Eastman, C Siegel, J Tousignant, AE Smith, SH Cheng, RK Scheule
Biochimica et Biophysica Acta (BBA)-Biomembranes 1325 (1), 41-62, 1997
3481997
CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy
MA Passini, J Bu, EM Roskelley, AM Richards, SP Sardi, CR O’Riordan, ...
The Journal of clinical investigation 120 (4), 1253-1264, 2010
3432010
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
SP Sardi, J Clarke, C Kinnecom, TJ Tamsett, L Li, LM Stanek, MA Passini, ...
Proceedings of the National Academy of Sciences 108 (29), 12101-12106, 2011
3392011
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