A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore BA Krantz, RA Melnyk, S Zhang, SJ Juris, DB Lacy, Z Wu, A Finkelstein, ... Science 309 (5735), 777-781, 2005 | 321 | 2005 |
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation DB Lacy, DJ Wigelsworth, RA Melnyk, SC Harrison, RJ Collier Proceedings of the National Academy of Sciences 101 (36), 13147-13151, 2004 | 280 | 2004 |
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms P Baker, PJ Hill, BD Snarr, N Alnabelseya, MJ Pestrak, MJ Lee, ... Science advances 2 (5), e1501632, 2016 | 167 | 2016 |
The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication RA Melnyk, S Kim, AR Curran, DM Engelman, JU Bowie, CM Deber Journal of Biological Chemistry 279 (16), 16591-16597, 2004 | 145 | 2004 |
Retention of native-like oligomerization states in transmembrane segment peptides: application to the Escherichia coli aspartate receptor RA Melnyk, AW Partridge, CM Deber Biochemistry 40 (37), 11106-11113, 2001 | 106 | 2001 |
Polar residue tagging of transmembrane peptides RA Melnyk, AW Partridge, J Yip, Y Wu, NK Goto, CM Deber Peptide Science 71 (6), 675-685, 2003 | 105 | 2003 |
Sequence context strongly modulates association of polar residues in transmembrane helices JP Dawson, RA Melnyk, CM Deber, DM Engelman Journal of molecular biology 331 (1), 255-262, 2003 | 104 | 2003 |
A rapid method for the determination of vitamin E forms in tissues and diet by high‐performance liquid chromatography using a normal‐phase diol column JKG Kramer, L Blais, RC Fouchard, RA Melnyk, KMR Kallury Lipids 32 (3), 323-330, 1997 | 103 | 1997 |
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants PM Gorman, S Kim, M Guo, RA Melnyk, J McLaurin, PE Fraser, JU Bowie, ... BMC neuroscience 9 (1), 1-11, 2008 | 91 | 2008 |
Crystal structure of Clostridium difficile toxin A NM Chumbler, SA Rutherford, Z Zhang, MA Farrow, JP Lisher, E Farquhar, ... Nature microbiology 1 (1), 1-6, 2016 | 83 | 2016 |
Transmembrane domain mediated self-assembly of major coat protein subunits from Ff bacteriophage RA Melnyk, AW Partridge, CM Deber Journal of molecular biology 315 (1), 63-72, 2002 | 79 | 2002 |
A model of anthrax toxin lethal factor bound to protective antigen DB Lacy, HC Lin, RA Melnyk, O Schueler-Furman, L Reither, ... Proceedings of the National Academy of Sciences 102 (45), 16409-16414, 2005 | 75 | 2005 |
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation RA Melnyk, RJ Collier Proceedings of the National Academy of Sciences 103 (26), 9802-9807, 2006 | 72 | 2006 |
Polar residues in membrane domains of proteins: Molecular basis for helix− helix association in a mutant CFTR transmembrane segment AW Partridge, RA Melnyk, CM Deber Biochemistry 41 (11), 3647-3653, 2002 | 71 | 2002 |
Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage J Tam, GL Beilhartz, A Auger, P Gupta, AG Therien, RA Melnyk Chemistry & biology 22 (2), 175-185, 2015 | 67 | 2015 |
Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore Z Zhang, M Park, J Tam, A Auger, GL Beilhartz, DB Lacy, RA Melnyk Proceedings of the National Academy of Sciences 111 (10), 3721-3726, 2014 | 62 | 2014 |
Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen RA Melnyk, KM Hewitt, DB Lacy, HC Lin, CR Gessner, S Li, VL Woods, ... Journal of Biological Chemistry 281 (3), 1630-1635, 2006 | 50 | 2006 |
Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants P Gupta, Z Zhang, SN Sugiman-Marangos, J Tam, S Raman, JP Julien, ... Journal of Biological Chemistry 292 (42), 17290-17301, 2017 | 48 | 2017 |
A transmembrane segment mimic derived from Escherichia coli diacylglycerol kinase inhibits protein activity AW Partridge, RA Melnyk, D Yang, JU Bowie, CM Deber Journal of Biological Chemistry 278 (24), 22056-22060, 2003 | 46 | 2003 |
Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation DS Wimalasena, JC Cramer, BE Janowiak, SJ Juris, RA Melnyk, ... Biochemistry 46 (51), 14928-14936, 2007 | 42 | 2007 |