Roman A. Melnyk, PhD
Roman A. Melnyk, PhD
The Hospital for Sick Children
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A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore
BA Krantz, RA Melnyk, S Zhang, SJ Juris, DB Lacy, Z Wu, A Finkelstein, ...
Science 309 (5735), 777-781, 2005
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation
DB Lacy, DJ Wigelsworth, RA Melnyk, SC Harrison, RJ Collier
Proceedings of the National Academy of Sciences 101 (36), 13147-13151, 2004
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
P Baker, PJ Hill, BD Snarr, N Alnabelseya, MJ Pestrak, MJ Lee, ...
Science advances 2 (5), e1501632, 2016
The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication
RA Melnyk, S Kim, AR Curran, DM Engelman, JU Bowie, CM Deber
Journal of Biological Chemistry 279 (16), 16591-16597, 2004
Retention of native-like oligomerization states in transmembrane segment peptides: application to the Escherichia coli aspartate receptor
RA Melnyk, AW Partridge, CM Deber
Biochemistry 40 (37), 11106-11113, 2001
Polar residue tagging of transmembrane peptides
RA Melnyk, AW Partridge, J Yip, Y Wu, NK Goto, CM Deber
Peptide Science 71 (6), 675-685, 2003
Sequence context strongly modulates association of polar residues in transmembrane helices
JP Dawson, RA Melnyk, CM Deber, DM Engelman
Journal of molecular biology 331 (1), 255-262, 2003
A rapid method for the determination of vitamin E forms in tissues and diet by high‐performance liquid chromatography using a normal‐phase diol column
JKG Kramer, L Blais, RC Fouchard, RA Melnyk, KMR Kallury
Lipids 32 (3), 323-330, 1997
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
PM Gorman, S Kim, M Guo, RA Melnyk, J McLaurin, PE Fraser, JU Bowie, ...
BMC neuroscience 9 (1), 1-11, 2008
Crystal structure of Clostridium difficile toxin A
NM Chumbler, SA Rutherford, Z Zhang, MA Farrow, JP Lisher, E Farquhar, ...
Nature microbiology 1 (1), 1-6, 2016
Transmembrane domain mediated self-assembly of major coat protein subunits from Ff bacteriophage
RA Melnyk, AW Partridge, CM Deber
Journal of molecular biology 315 (1), 63-72, 2002
A model of anthrax toxin lethal factor bound to protective antigen
DB Lacy, HC Lin, RA Melnyk, O Schueler-Furman, L Reither, ...
Proceedings of the National Academy of Sciences 102 (45), 16409-16414, 2005
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation
RA Melnyk, RJ Collier
Proceedings of the National Academy of Sciences 103 (26), 9802-9807, 2006
Polar residues in membrane domains of proteins: Molecular basis for helix− helix association in a mutant CFTR transmembrane segment
AW Partridge, RA Melnyk, CM Deber
Biochemistry 41 (11), 3647-3653, 2002
Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage
J Tam, GL Beilhartz, A Auger, P Gupta, AG Therien, RA Melnyk
Chemistry & biology 22 (2), 175-185, 2015
Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore
Z Zhang, M Park, J Tam, A Auger, GL Beilhartz, DB Lacy, RA Melnyk
Proceedings of the National Academy of Sciences 111 (10), 3721-3726, 2014
Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen
RA Melnyk, KM Hewitt, DB Lacy, HC Lin, CR Gessner, S Li, VL Woods, ...
Journal of Biological Chemistry 281 (3), 1630-1635, 2006
Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants
P Gupta, Z Zhang, SN Sugiman-Marangos, J Tam, S Raman, JP Julien, ...
Journal of Biological Chemistry 292 (42), 17290-17301, 2017
A transmembrane segment mimic derived from Escherichia coli diacylglycerol kinase inhibits protein activity
AW Partridge, RA Melnyk, D Yang, JU Bowie, CM Deber
Journal of Biological Chemistry 278 (24), 22056-22060, 2003
Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation
DS Wimalasena, JC Cramer, BE Janowiak, SJ Juris, RA Melnyk, ...
Biochemistry 46 (51), 14928-14936, 2007
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