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David Heppner
David Heppner
J. Solo Assistant Professor of Medicinal Chemistry, The State University of New York at Buffalo
Verified email at buffalo.edu - Homepage
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Cited by
Cited by
Year
Copper active sites in biology
EI Solomon, DE Heppner, EM Johnston, JW Ginsbach, J Cirera, ...
Chemical reviews 114 (7), 3659-3853, 2014
16612014
A quantitative tissue-specific landscape of protein redox regulation during aging
H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ...
Cell 180 (5), 968-983. e24, 2020
3062020
Single and dual targeting of mutant EGFR with an allosteric inhibitor
C To, J Jang, T Chen, E Park, M Mushajiang, DJH De Clercq, M Xu, ...
Cancer discovery 9 (7), 926-943, 2019
2752019
Copper dioxygen (bio) inorganic chemistry
EI Solomon, JW Ginsbach, DE Heppner, MT Kieber-Emmons, ...
Faraday discussions 148, 11-39, 2011
2012011
Reaction coordinate of a functional model of tyrosinase: spectroscopic and computational characterization
BT Op’t Holt, MA Vance, LM Mirica, DE Heppner, TDP Stack, EI Solomon
Journal of the American Chemical Society 131 (18), 6421-6438, 2009
1322009
Direct cysteine sulfenylation drives activation of the Src kinase
DE Heppner, CM Dustin, C Liao, M Hristova, C Veith, AC Little, BA Ahlers, ...
Nature communications 9 (1), 4522, 2018
1162018
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer
C To, TS Beyett, J Jang, WW Feng, M Bahcall, HM Haikala, BH Shin, ...
Nature Cancer 3 (4), 402-417, 2022
962022
Redox-dependent regulation of epidermal growth factor receptor signaling
DE Heppner, A van der Vliet
Redox Biology 8, 24-27, 2016
832016
DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma
A Habibovic, M Hristova, DE Heppner, K Danyal, JL Ather, ...
JCI insight 1 (18), 2016
782016
Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?
DE Heppner, M Hristova, T Ida, A Mijuskovic, CM Dustin, V Bogdándi, ...
Redox biology 14, 379-385, 2018
762018
Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors
DJH De Clercq, DE Heppner, C To, J Jang, E Park, CH Yun, ...
ACS Medicinal Chemistry Letters 10 (11), 1549-1553, 2019
712019
Dual oxidase: a novel therapeutic target in allergic disease
A van der Vliet, K Danyal, DE Heppner
British journal of pharmacology 175 (9), 1401-1418, 2018
682018
DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties
AC Little, D Sham, M Hristova, K Danyal, DE Heppner, RA Bauer, ...
Oncogenesis, e261, 2016
662016
The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling
DE Heppner, M Hristova, CM Dustin, K Danyal, A Habibovic, ...
Journal of Biological Chemistry 291 (44), 23282, 2016
642016
Redox regulation of tyrosine kinase signalling: more than meets the eye
CM Dustin, DE Heppner, MCJ Lin, A van der Vliet
The Journal of Biochemistry 167 (2), 151-163, 2020
622020
Mechanism of the reduction of the native intermediate in the multicopper oxidases: Insights into rapid intramolecular electron transfer in turnover
DE Heppner, CH Kjaergaard, EI Solomon
Journal of the American Chemical Society 136 (51), 17788-17801, 2014
622014
The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies
DE Heppner, YMW Janssen-Heininger, A van der Vliet
Archives of Biochemistry and Biophysics 616, 40-46, 2017
592017
Architecture of the NADPH oxidase family of enzymes
BC Ogboo, UV Grabovyy, A Maini, S Scouten, A van der Vliet, A Mattevi, ...
Redox Biology 52, 102298, 2022
542022
Models for dioxygen activation by the CuB site of dopamine β-monooxygenase and peptidylglycine α-hydroxylating monooxygenase
BF Gherman, DE Heppner, WB Tolman, CJ Cramer
JBIC Journal of Biological Inorganic Chemistry 11, 197-205, 2006
542006
Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics
N Chamberlain, BR Korwin-Mihavics, EM Nakada, SR Bruno, ...
Redox biology 22, 101129, 2019
522019
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