David E. Heppner
David E. Heppner
J. Solo Assistant Professor, University at Buffalo, State University of New York
Verified email at buffalo.edu
Cited by
Cited by
Copper active sites in biology
EI Solomon, DE Heppner, EM Johnston, JW Ginsbach, J Cirera, ...
Chemical reviews 114 (7), 3659-3853, 2014
Copper dioxygen (bio) inorganic chemistry
EI Solomon, JW Ginsbach, DE Heppner, MT Kieber-Emmons, ...
Faraday discussions 148, 11-39, 2011
Reaction coordinate of a functional model of tyrosinase: spectroscopic and computational characterization
BT Op’t Holt, MA Vance, LM Mirica, DE Heppner, TDP Stack, EI Solomon
Journal of the American Chemical Society 131 (18), 6421-6438, 2009
Redox-dependent regulation of epidermal growth factor receptor signaling
DE Heppner, A van der Vliet
Redox Biology 8, 24-27, 2016
Single and dual targeting of mutant EGFR with an allosteric inhibitor
C To, J Jang, T Chen, E Park, M Mushajiang, DJH De Clercq, M Xu, ...
Cancer discovery 9 (7), 926-943, 2019
Models for dioxygen activation by the CuB site of dopamine β-monooxygenase and peptidylglycine α-hydroxylating monooxygenase
BF Gherman, DE Heppner, WB Tolman, CJ Cramer
JBIC Journal of Biological Inorganic Chemistry 11 (2), 197-205, 2006
DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma
A Habibovic, M Hristova, DE Heppner, K Danyal, JL Ather, ...
JCI insight 1 (18), 2016
Direct cysteine sulfenylation drives activation of the Src kinase
DE Heppner, CM Dustin, C Liao, M Hristova, C Veith, AC Little, BA Ahlers, ...
Nature communications 9 (1), 1-11, 2018
Validation of density functional modeling protocols on experimental bis(μ-oxo)/μ-η22-peroxo dicopper equilibria
JL Lewin, DE Heppner, CJ Cramer
JBIC Journal of Biological Inorganic Chemistry 12 (8), 1221-1234, 2007
A quantitative tissue-specific landscape of protein redox regulation during aging
H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ...
Cell 180 (5), 968-983. e24, 2020
Mechanism of the reduction of the native intermediate in the multicopper oxidases: Insights into rapid intramolecular electron transfer in turnover
DE Heppner, CH Kjaergaard, EI Solomon
Journal of the American Chemical Society 136 (51), 17788-17801, 2014
DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties
AC Little, D Sham, M Hristova, K Danyal, DE Heppner, RA Bauer, ...
Oncogenesis, e261, 2016
The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling
DE Heppner, M Hristova, CM Dustin, K Danyal, A Habibovic, ...
Journal of Biological Chemistry 291 (44), 23282, 2016
Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?
DE Heppner, M Hristova, T Ida, A Mijuskovic, CM Dustin, V Bogdándi, ...
Redox biology 14, 379-385, 2018
Molecular origin of rapid versus slow intramolecular electron transfer in the catalytic cycle of the multicopper oxidases
DE Heppner, CH Kjaergaard, EI Solomon
Journal of the American Chemical Society 135 (33), 12212-12215, 2013
The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies
DE Heppner, YMW Janssen-Heininger, A van der Vliet
Archives of Biochemistry and Biophysics 616, 40-46, 2017
Paradoxical Roles of Dual Oxidases in Cancer Biology
AC Little, A Sulovari, K Danyal, DE Heppner, DJ Seward, A van der Vliet
Free Radical Biology and Medicine 110, 117-132, 2017
Dual oxidase: a novel therapeutic target in allergic disease
A van der Vliet, K Danyal, DE Heppner
British journal of pharmacology 175 (9), 1401-1418, 2018
Redox regulation of tyrosine kinase signalling: more than meets the eye
CM Dustin, DE Heppner, MCJ Lin, A van der Vliet
The Journal of Biochemistry 167 (2), 151-163, 2020
Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors
DJH De Clercq, DE Heppner, C To, J Jang, E Park, CH Yun, ...
ACS Medicinal Chemistry Letters 10 (11), 1549-1553, 2019
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